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DOI 10.1016/j.seizure.2018.01.015

Медицинская библиотека · Seizure · 2018

Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial.

Tacke Moritz, Borggraefe Ingo, Gerstl Lucia, Heinen Florian, Vill Katharina, Bonfert Michaela, Bast Thomas, HEAD Study group, Neubauer Bernd Axel, Baumeister Friedrich, Baethmann Martina, Bentele Karl, Blank Christian, Blank Harald M, Bode Harald, Bosch Friedrich, Brandl Ulrich, Brockmann Knut, Dahlem Peter, Ernst Jan-Peter, Feldmann Evemarie, Fiedler Andreas, Gerigk Michael, Heß Soeren, Hikel Christiane, Hoffmann Hans-Georg, Kieslich Matthias, Klepper Joerg, Kluger Gerhard, Koch Hartmut, Koch Walter, Korinthenberg Rudolf, Krois Ilona, Kühne Hermann, Kurlemann Gerhard, Mandl Michaela, Mause Ulrike, Navratil Peter, Opp Joachim, Penzien Johann, Prietsch Viola, Quattländer Axel, Rating Dietz, Schara Ulrike, Shamdeen Mohammed G, Sprinz Andreas, Wendker-Magrabi Hildegard, Stephani Ulrich, Muhle Hiltrud, Straßburg Hans-Michael, Töpke Bärbel, Trollmann Regina, Tuschen-Hofstätter Elisabeth, Waltz Stephan, Weber Gabriele, Wien Frank U, Wolff Markus, Polster Tilman, Freitag Hedwig, Sönmez Ötzcam, Reinhardt Klaus, Traus Marion, Hoovey Zeecam

СтатьяМногоцентровое исследованиеРандомизированное исследованиеПеревод пока не подготовлен

Аннотация

PURPOSE: BECTS (benign childhood epilepsy with centrotemporal spikes) is associated with characteristic EEG findings. This study examines the influence of anti-convulsive treatment on the EEG.

METHODS

In a randomized controlled trial including 43 children with BECTS, EEGs were performed prior to treatment with either Sulthiame or Levetiracetam as well as three times under treatment. Using the spike-wave-index, the degree of EEG pathology was quantified. The EEG before and after initiation of treatment was analyzed. Both treatment arms were compared and the EEG of the children that were to develop recurrent seizures was compared with those that were successfully treated.

RESULTS

Regardless of the treatment agent, the spike-wave-index was reduced significantly under treatment. There were no differences between the two treatment groups. In an additional analysis, the EEG characteristics of the children with recurrent seizures differed statistically significant from those that did not have any further seizures.

CONCLUSION

Both Sulthiame and Levetiracetam influence the EEG of children with BECTS. Persistent EEG pathologies are associated with treatment failures.

Для цитирования: Tacke Moritz, Borggraefe Ingo, Gerstl Lucia, Heinen Florian, Vill Katharina, Bonfert Michaela, Bast Thomas, HEAD Study group, Neubauer Bernd Axel, Baumeister Friedrich, Baethmann Martina, Bentele Karl, Blank Christian, Blank Harald M, Bode Harald, Bosch Friedrich, Brandl Ulrich, Brockmann Knut, Dahlem Peter, Ernst Jan-Peter, Feldmann Evemarie, Fiedler Andreas, Gerigk Michael, Heß Soeren, Hikel Christiane, Hoffmann Hans-Georg, Kieslich Matthias, Klepper Joerg, Kluger Gerhard, Koch Hartmut, Koch Walter, Korinthenberg Rudolf, Krois Ilona, Kühne Hermann, Kurlemann Gerhard, Mandl Michaela, Mause Ulrike, Navratil Peter, Opp Joachim, Penzien Johann, Prietsch Viola, Quattländer Axel, Rating Dietz, Schara Ulrike, Shamdeen Mohammed G, Sprinz Andreas, Wendker-Magrabi Hildegard, Stephani Ulrich, Muhle Hiltrud, Straßburg Hans-Michael, Töpke Bärbel, Trollmann Regina, Tuschen-Hofstätter Elisabeth, Waltz Stephan, Weber Gabriele, Wien Frank U, Wolff Markus, Polster Tilman, Freitag Hedwig, Sönmez Ötzcam, Reinhardt Klaus, Traus Marion, Hoovey Zeecam. Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial.. Seizure. 2018. DOI: 10.1016/j.seizure.2018.01.015.

Предметные рубрики MeSH

AnticonvulsantsBrain WavesChildDouble-Blind MethodElectroencephalographyEpilepsy, RolandicFemaleGermanyHumansLevetiracetamMalePiracetamRetrospective StudiesStatistics, NonparametricThiazinesTreatment OutcomeBenzenesulfonamides
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