[Morphologic changes of gastric mucosa in Helicobacter pylori infection in patients with peptic ulcer disease and chronic gastritis].

The present study was carried out to value the histological method of detection of Helicobacter pylori in gastric mucosa and to analyse the pathological changes of the Helicobacter pylori-positive patients with duodenal and gastric ulcer and with chronic gastritis. The studies population consisted of 150 patients, 76 F and 74 M. The samples were taken during gastroscopy from the prepyloric region and gastric body. After routine histological procedure they were stained HE and by Giemsa method for detection of H.pylori. The latter was identified in 56.6% of of the patients with duodenal ulcer, in 54.8% of those with gastric ulcer, in 17.6% of the patients after partial gastrectomy and in 46.9% of patients suffering from chronic gastritis. The increased density of H.pylori (third grade) was detected in the cases with clinical diagnosis of duodenal and gastric ulcer and erythematous endoscopic gastritis and was correlated with the histological picture of chronic active gastritis, which was characterized by diffuse mixed cellular exudation, lesion of the superficial epithelial, mucosal erosions and by foveolar hyperplasia. We suggest that this morphological picture corresponded to the active phase of Helicobacter infection. We conclude, that the histological method by Giemsas staining is effective especially in the acute phase of H.pylori infection and represents high diagnostic value and may be used in monitoring during the antibacterial (anti H.pylori) treatment. There is the correlation between massive density of H.pylori observed in gastric mucosa and chronic active gastritis.