Acta obstetricia et gynecologica Scandinavica · 2011
Ultrasonographic extended-view technique for evaluation of abdominal fat distribution in lean women with polycystic ovary syndrome.
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Battaglia Cesare, Battaglia Bruno, Mancini Fulvia, Paradisi Roberto, Fabbri Raffaella, Venturoli Stefano
Аннотация
OBJECTIVE: To estimate whether, by using a new ultrasonographic technique (extended view; XTD view), young lean women with polycystic ovary syndrome (PCOS) have a more android fat distribution in comparison with normally menstruating women with ultrasonographic evidence of polycystic ovaries (PCO) and healthy control subjects, matched for both age and body mass index.
DESIGN: Prospective observational study.
SETTING: University Hospital.
SAMPLE: Forty-nine lean women with PCOS, 42 eumenorrheic women with bilateral PCO and 40 healthy volunteers with regular ovulatory cycles.
METHODS: Fasting blood sampling, ultrasonographic and Doppler analyses and blood pressure monitoring.
MAIN OUTCOME MEASURES: Medical examination, biochemical and hormonal parameters, ultrasonographic abdominal fat measurements, ultrasonographic evaluation of carotid intima-media thickness and Doppler analysis of ophthalmic artery. An oral glucose tolerance test was performed to analyze glucose, insulin and C-peptide levels.
RESULTS: The XTD ultrasonographic preperitoneal area was significantly larger in women with PCOS than in control subjects (p=0.011). The preperitoneal/subcutaneous ratio was significantly higher in women with PCOS (1.1±0.26) compared with women with PCO (0.84±0.13; p=0.05) and control women (0.67±0.13; p<0.001). The mean pulsatility index of ophthalmic arteries was higher in the PCOS women (1.93±0.57) than in control subjects (1.84±0.38; p=0.041). Total cholesterol, triglycerides and LDL cholesterol were significantly higher in women with PCOS than in those with PCO and in control subjects.
CONCLUSIONS: Women with PCOS have an android fat pattern correlated with an age-dependent increased risk of cardiovascular diseases.
DESIGN: Prospective observational study.
SETTING: University Hospital.
SAMPLE: Forty-nine lean women with PCOS, 42 eumenorrheic women with bilateral PCO and 40 healthy volunteers with regular ovulatory cycles.
METHODS: Fasting blood sampling, ultrasonographic and Doppler analyses and blood pressure monitoring.
MAIN OUTCOME MEASURES: Medical examination, biochemical and hormonal parameters, ultrasonographic abdominal fat measurements, ultrasonographic evaluation of carotid intima-media thickness and Doppler analysis of ophthalmic artery. An oral glucose tolerance test was performed to analyze glucose, insulin and C-peptide levels.
RESULTS: The XTD ultrasonographic preperitoneal area was significantly larger in women with PCOS than in control subjects (p=0.011). The preperitoneal/subcutaneous ratio was significantly higher in women with PCOS (1.1±0.26) compared with women with PCO (0.84±0.13; p=0.05) and control women (0.67±0.13; p<0.001). The mean pulsatility index of ophthalmic arteries was higher in the PCOS women (1.93±0.57) than in control subjects (1.84±0.38; p=0.041). Total cholesterol, triglycerides and LDL cholesterol were significantly higher in women with PCOS than in those with PCO and in control subjects.
CONCLUSIONS: Women with PCOS have an android fat pattern correlated with an age-dependent increased risk of cardiovascular diseases.