Radical Resection in an Era of Immune Therapy for Primary Esophageal Melanoma.

Primary malignant melanoma of the esophagus (PMME) is a rare and aggressive esophageal malignant neoplasm demonstrating poor overall survival. Immunotherapy (IO) is now established as a therapy for aggressive or metastatic cutaneous malignant melanoma. This case series discusses IO for PMME in both the perioperative and salvage setting for curative intent. IO is changing the treatment approaches for PMME and may lead to long-term salvage and survival.