Journal of psychiatric research · 2025
Brain functional changes in juvenile delinquents: a preliminary meta-analysis.
СтатьяМетаанализПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wang Yong-Ming, Yang Jia-Sheng, Liu Xin-Qi, Bie Qing-Wen, Xie Yu-Shan, Zhang Meng, Tao Lu-Yang, Chen Xi-Ping
Аннотация
BACKGROUND: Juvenile delinquency is a serious social issue that poses significant challenges to public safety and mental health systems. However, the neurophysiological mechanisms underlying delinquent behaviour in juveniles remain unclear. In this meta-analysis, we aimed to investigate the functional brain characteristics during resting-state and task-based conditions in juvenile offenders.
METHODS: A comprehensive literature search was conducted in PubMed, Web of Science and MEDLINE, focusing on whole-brain resting-state and task-based functional magnetic resonance imaging (fMRI) studies examining brain activation patterns in juvenile delinquents compared with controls.
RESULTS: Six task-based fMRI studies were incorporated into the meta-analysis. Our findings revealed increased activation in juvenile delinquents in the left medial orbital part of the superior frontal gyrus (SFG), amygdala and cerebellum vermis VI region across these task-based fMRI studies, and increased activation in the left medial orbital part of the SFG and vermis VI region in studies using emotional tasks. The other five resting-state fMRI studies reported different indicators. Therefore, no meta-analysis was performed on the resting-state data.
CONCLUSION: These findings suggest that overactivation in the fronto-amygdala-cerebellar circuit may be a key neurophysiological basis for impaired emotional and behavioural regulation, as well as increased violent behaviour in juvenile offenders.
METHODS: A comprehensive literature search was conducted in PubMed, Web of Science and MEDLINE, focusing on whole-brain resting-state and task-based functional magnetic resonance imaging (fMRI) studies examining brain activation patterns in juvenile delinquents compared with controls.
RESULTS: Six task-based fMRI studies were incorporated into the meta-analysis. Our findings revealed increased activation in juvenile delinquents in the left medial orbital part of the superior frontal gyrus (SFG), amygdala and cerebellum vermis VI region across these task-based fMRI studies, and increased activation in the left medial orbital part of the SFG and vermis VI region in studies using emotional tasks. The other five resting-state fMRI studies reported different indicators. Therefore, no meta-analysis was performed on the resting-state data.
CONCLUSION: These findings suggest that overactivation in the fronto-amygdala-cerebellar circuit may be a key neurophysiological basis for impaired emotional and behavioural regulation, as well as increased violent behaviour in juvenile offenders.