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DOI 10.1126/science.ads9960

Медицинская библиотека · Science (New York, N.Y.) · 2025

Superstable lipid vacuoles endow cartilage with its shape and biomechanics.

Ramos Raul, Pham Kim T, Prince Richard C, Leiser-Miller Leith B, Prasad Maneeshi S, Wang Xiaojie, Nordberg Rachel C, Bielajew Benjamin J, Hu Jerry C, Yamaga Kosuke, Oh Ji Won, Peng Tao, Datta Rupsa, Astrowskaja Aksana, Almet Axel A, Burns John T, Liu Yuchen, Guerrero-Juarez Christian Fernando, Tran Bryant Q, Chu Yi-Lin, Nguyen Anh M, Hsi Tsai-Ching, Lim Norman T-L, Schoeniger Sandra, Liu Ruiqi, Pai Yun-Ling, Vadivel Chella K, Ingleby Sandy, McKechnie Andrew E, van Breukelen Frank, Hoehn Kyle L, Rasweiler John J, Kohara Michinori, Loughry William J, Weldy Scott H, Cosper Raymond, Yang Chao-Chun, Lin Sung-Jan, Cooper Kimberly L, Santana Sharlene E, Bradley Jeffrey E, Kiebish Michael A, Digman Michelle, James David E, Merrill Amy E, Nie Qing, Schilling Thomas F, Astrowski Aliaksandr A, Potma Eric O, García-Castro Martín I, Athanasiou Kyriacos A, Behringer Richard R, Plikus Maksim V

СтатьяПоддержка правительства СШАПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis. Consequently, lipochondrocytes grew uniform lipid droplets that resisted systemic lipid surges and did not enlarge upon obesity. Lipochondrocytes also lacked lipid mobilization factors, which enabled exceptional vacuole stability and protected cartilage from shrinking upon starvation. Lipid droplets modulated lipocartilage biomechanics by decreasing the tissue's stiffness, strength, and resilience. Lipochondrocytes were found in multiple mammals, including humans, but not in nonmammalian tetrapods. Thus, analogous to bubble wrap, superstable lipid vacuoles confer skeletal tissue with cartilage-like properties without "packing foam-like" extracellular matrix.

Для цитирования: Ramos Raul, Pham Kim T, Prince Richard C, Leiser-Miller Leith B, Prasad Maneeshi S, Wang Xiaojie, Nordberg Rachel C, Bielajew Benjamin J, Hu Jerry C, Yamaga Kosuke, Oh Ji Won, Peng Tao, Datta Rupsa, Astrowskaja Aksana, Almet Axel A, Burns John T, Liu Yuchen, Guerrero-Juarez Christian Fernando, Tran Bryant Q, Chu Yi-Lin, Nguyen Anh M, Hsi Tsai-Ching, Lim Norman T-L, Schoeniger Sandra, Liu Ruiqi, Pai Yun-Ling, Vadivel Chella K, Ingleby Sandy, McKechnie Andrew E, van Breukelen Frank, Hoehn Kyle L, Rasweiler John J, Kohara Michinori, Loughry William J, Weldy Scott H, Cosper Raymond, Yang Chao-Chun, Lin Sung-Jan, Cooper Kimberly L, Santana Sharlene E, Bradley Jeffrey E, Kiebish Michael A, Digman Michelle, James David E, Merrill Amy E, Nie Qing, Schilling Thomas F, Astrowski Aliaksandr A, Potma Eric O, García-Castro Martín I, Athanasiou Kyriacos A, Behringer Richard R, Plikus Maksim V. Superstable lipid vacuoles endow cartilage with its shape and biomechanics.. Science (New York, N.Y.). 2025. DOI: 10.1126/science.ads9960.

Предметные рубрики MeSH

AnimalsHumansMiceAdipocytesBiomechanical PhenomenaCartilageExtracellular MatrixLipid DropletsLipid MetabolismLipogenesisObesityVacuoles
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