Leukemia & lymphoma · 2023
Utility of routine pulmonary function test after autologous hematopoietic cell transplantation in lymphoma.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Dahi Parastoo B, Kenny Sheila, Flynn Jessica, Devlin Sean M, Ruiz Josel D, Chinapen Stephanie A, Lahoud Oscar B, Matasar Matthew J, Moskowitz Craig H, Perales Miguel-Angel, Shah Gunjan, Sauter Craig S, Giralt Sergio A, Geyer Alexander I, Jakubowski Ann A
Аннотация
This study aims to evaluate the predictive value of routine pulmonary function testing (PFT) at the 12-month mark post-autologous hematopoietic cell transplant (AHCT) in identifying clinically significant lung disease in lymphoma survivors. In 247 patients, 173 (70%) received BEAM (carmustine, etoposide, cytarabine, melphalan), and 49 (20%) received TBC (thiotepa, busulfan, cyclophosphamide) conditioning regimens. Abnormal baseline PFT was noted in 149 patients (60%). Thirty-four patients had a significant decline (reduction of >/= 20% in DLCO or FEV1 or FVC) in post-AHCT PFT, with the highest incidence in the CNS lymphoma group (39%). The incidence of clinically significant lung disease post-transplant was low at 2% and there was no association between abnormal pre- and 1-year post-transplant PFTs with the development of clinical lung disease. While this study illustrates the impact of treatment regimens on PFT changes, it did not demonstrate a predictive value of scheduled PFTs in identifying clinically significant post-AHCT lung disease.