Internal medicine (Tokyo, Japan) · 2022
Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sato Aya, Imai Yukinori, Uchiya Hiroshi, Uchida Yoshihito, Nakazawa Manabu, Sugawara Kayoko, Nakayama Nobuaki, Mochida Satoshi
Аннотация
We herein report two patients with hepatocellular carcinoma (HCC) who exhibited intraabdominal bleeding caused by tumor rupture soon after lenvatinib initiation. A hypervascular nodule was present in the lateral segment manifesting extrahepatic protrusion in an 81-year-old-man and in the caudate lobe, which was completely occupied by the tumor, in an 83-year-old-man. Both patients were given lenvatinib, and epigastralgia occurred suddenly three and five days later. Computed tomography revealed high-attenuation areas suggesting bleeding around the left and caudate lobes. Considering the strong antiangiogenic effects by lenvatinib, transcatheter arterial embolization should be performed before lenvatinib initiation in patients with subcapsular HCC.