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Войти в исследования Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Pseudo normative pattern electroretinograms in young children and infants.
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Liasis Alkiviades, Hagan Richard P, Nischal Ken K
Аннотация
PURPOSE: Review Pattern Electroretinogram (PERG) data from a pediatric population to characterize the development of response.
METHODS: A case review of 104 subjects who had PERG aged between 0 and 9 years of age as part of routine clinical testing who were categorized as normal. PERG responses were recorded with skin electrodes, with the stimulus presented on a 40o screen. The main outcome measures were the amplitude and timing of the main components of the PERG, the P50 and N95.
RESULTS: An increase in P50 amplitude was noted over the first 2 years of life, a less rapid increase in amplitude was observed after this. The P50 timing was noted to decrease in the first 6 months but stabilized after this. A similar increase in amplitude was observed for the N95 amplitude with a modest decrease in latency.
CONCLUSION: This study has shown an increase in PERG amplitude beyond the first 6 months of life with the most rapid rate of increase of response occurring in the first 2 years. This physiological data potentially documents the functional maturation of the human macula that parallels the anatomical changes noted via histology.
KEY MESSAGES: Robust PERG responses are possible in pediatric cases recorded with skin electrode to widefield stimuli, even in young infants. Paper provides evidence of physiological development of macula that correlates well with previously documented anatomical maturation.
METHODS: A case review of 104 subjects who had PERG aged between 0 and 9 years of age as part of routine clinical testing who were categorized as normal. PERG responses were recorded with skin electrodes, with the stimulus presented on a 40o screen. The main outcome measures were the amplitude and timing of the main components of the PERG, the P50 and N95.
RESULTS: An increase in P50 amplitude was noted over the first 2 years of life, a less rapid increase in amplitude was observed after this. The P50 timing was noted to decrease in the first 6 months but stabilized after this. A similar increase in amplitude was observed for the N95 amplitude with a modest decrease in latency.
CONCLUSION: This study has shown an increase in PERG amplitude beyond the first 6 months of life with the most rapid rate of increase of response occurring in the first 2 years. This physiological data potentially documents the functional maturation of the human macula that parallels the anatomical changes noted via histology.
KEY MESSAGES: Robust PERG responses are possible in pediatric cases recorded with skin electrode to widefield stimuli, even in young infants. Paper provides evidence of physiological development of macula that correlates well with previously documented anatomical maturation.