[Clinicopathogenetic variants of anemia in patients with intestinal inflammation].

AIM: To study factors of anemia pathogenesis in patients with ulcerative colitis (UC) and Crohn's disease (CD).

MATERIAL AND

METHODS

A total of 80 patients (56% males and 44% females, mean age 39 +/- 15.8 years) with UC and CD were divided into two groups: group 1--40 patients with anemia, group 2--40 controls free of anemia with the same gender characteristics. The examination protocol included: total blood count, parameters of iron metabolism (TIBC, LIBC, transferrin saturation with iron, ferritin, transferring, etc.), the levels of erythropoietin, C-reactive protein, TNF-alpha, hepsidin, vitamin B12, folic acid.

RESULTS

Group 1 patients had a significantly lower, mean level of iron in the blood and transferrin saturation with iron while the other parameters of iron metabolism (TIBC, LIBC, transferrin, ferritin) did not significantly differ from these of group 2.

CONCLUSION

Anemia in intestinal inflammation is an independent disease with complicated pathogenesis. This demands complete examination of such patients to prescribe adequate combined treatment of anemia with consideration of all pathogenetic factors of its development.