Bolus corticosteroids and cyclophosphamide for initial treatment of Wegener's granulomatosis.

Wegener's granulomatosis, a necrotizing vasculitis involving primarily the upper and lower respiratory tract and the kidney, may be rapidly fatal. We describe two children with Wegener's granulomatosis in whom we observed dramatic improvement within 72 hours following bolus corticosteroid therapy combined with cyclophosphamide.