Age related signal changes of the pituitary stalk on thin-slice magnetic resonance imaging in infants.

PURPOSE: Signals of some brain regions change along with development in T1-weighted imaging (T1WI) in infants. This study aimed to assess the association of the signal intensity of the pituitary stalk on thin-slice T1WI with infant age.

METHODS

This retrospective study was performed in 89 infants (gestational age [GA], 25-41 weeks; postmenstrual age [PMA], 36-46 weeks; chronological age [CA], 4-141 days) without intracranial abnormalities. The signal ratio of the pituitary stalk/pons on thin-slice T1WI was calculated, and its correlations with GA, PMA, and CA were assessed. Additionally, the signal ratio of the anterior pituitary gland/pons was calculated, and its correlation with that of the pituitary stalk was assessed. The signal intensity and distribution of the pituitary stalk were visually rated, and their correlations with GA, PMA, and CA were assessed.

RESULTS

The signal ratio of the pituitary stalk was significantly positively correlated with GA (P < 0.001) and negatively correlated with CA (P < 0.001), but was not correlated with PMA. Stepwise multiple regression revealed that CA was independently associated with the signal ratio of the pituitary stalk (P < 0.001). GA was significantly higher (P < 0.05) and CA was significantly lower (P < 0.05) in infants with a high signal intensity and wide distribution of high signal intensity of the pituitary stalk.

CONCLUSIONS

The signal intensity of the pituitary stalk on T1WI was negatively correlated with CA in infants, which might be related to postnatal changes in the pars tuberalis of the pituitary stalk after birth in infants.