Journal of the science of food and agriculture · 2025
Effect of apple peel powder and pomace extract on hyperlipidemic health indices of albino Wistar rats.
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Amjad Adnan, Syed Amna, Waseem Muhammad, Alshammari Jaza Maqbl, Kamal Md Murtuza, Akram Shazia, Israr Muhammad, Zafar Shehnshah, Osei Tutu Crossby
Аннотация
BACKGROUND: Hyperlipidemia is now considered a significant concern due to changes in human dietary lifestyles. These challenges have shifted the trend toward plant-based foods, as fruit parts and their extracts have shown therapeutic potential against several diseases due to their unique nutritional profile. In this study, the antihyperlipidemic activities of apple peel powder (APP) and apple pomace extract (APE) were examined in Wistar rats.
RESULTS: The results showed a significant (P < 0.05) decline in total cholesterol (from 268.5 to 96.5 mg dL-1), low-density lipoprotein cholesterol (from 200 to 43.6 mg dL-1) and triglyceride (from 198.45 to 98.14 mg dL-1), and a significant (P < 0.05) increase (from 28.2 to 34.3 mg dL-1) in high-density lipoprotein cholesterol was investigated. Heart histopathology revealed a significant (P < 0.05) improvement in myocardial degenerative and necrotic changes. Alongside, T4 (100 g kg-1 APE) revealed a significant (P < 0.05) improvement in liver parameters such as alanine transaminase (ALT) and aspartate transaminase (AST), which were also reduced in T1 (50 g kg-1 APP), T2 (100 g kg-1 APP) and T3 (50 g kg-1 APE). The highest bilirubin was noted in TPC (2.9 mg dL-1), whereas T4 showed the lowest values i.e., 1.5 mg dL-1. Furthermore, the findings for body and organ weights showed a notable decline for heart, kidney, liver, lungs and spleen.
CONCLUSION: The findings of the present study demonstrated a comparable impact of APP and APE at a dose of 100 g kg-1 supplementation, which has shown antihyperlipidemic activity in rats fed a high-fat diet. However, toxicological safety studies are needed to ascertain their dependent responses in humans. © 2025 Society of Chemical Industry.
RESULTS: The results showed a significant (P < 0.05) decline in total cholesterol (from 268.5 to 96.5 mg dL-1), low-density lipoprotein cholesterol (from 200 to 43.6 mg dL-1) and triglyceride (from 198.45 to 98.14 mg dL-1), and a significant (P < 0.05) increase (from 28.2 to 34.3 mg dL-1) in high-density lipoprotein cholesterol was investigated. Heart histopathology revealed a significant (P < 0.05) improvement in myocardial degenerative and necrotic changes. Alongside, T4 (100 g kg-1 APE) revealed a significant (P < 0.05) improvement in liver parameters such as alanine transaminase (ALT) and aspartate transaminase (AST), which were also reduced in T1 (50 g kg-1 APP), T2 (100 g kg-1 APP) and T3 (50 g kg-1 APE). The highest bilirubin was noted in TPC (2.9 mg dL-1), whereas T4 showed the lowest values i.e., 1.5 mg dL-1. Furthermore, the findings for body and organ weights showed a notable decline for heart, kidney, liver, lungs and spleen.
CONCLUSION: The findings of the present study demonstrated a comparable impact of APP and APE at a dose of 100 g kg-1 supplementation, which has shown antihyperlipidemic activity in rats fed a high-fat diet. However, toxicological safety studies are needed to ascertain their dependent responses in humans. © 2025 Society of Chemical Industry.