Head & neck · 2013
Results of 226 patients with T3 laryngeal carcinoma after treatment with transoral laser microsurgery.
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Canis Martin, Ihler Friedrich, Martin Alexios, Wolff Hendrik A, Matthias Christoph, Steiner Wolfgang
Аннотация
BACKGROUND: The purpose of this study was to assess the feasibility of transoral laser microsurgery (TLM) in treatment of pT3 laryngeal cancer.
METHODS: We conducted a retrospective case series study of 226 patients with pT3 glottic (n = 122; 54%) or supraglottic laryngeal carcinoma (n = 104; 46%). All patients were treated by TLM in combination with neck dissection (63%) and with postoperative radiotherapy (18%). Our main outcome measures were local control, organ preservation, functional outcome, overall survival, recurrence-free survival, and disease-specific survival.
RESULTS: Median follow-up period was 57.8 months. The 5-year organ-preservation and local control rates for all patients were 87% and 71.4%, respectively. The 5-year overall, recurrence-free, and disease-specific survival were 64.4%, 63.0%, and 83.3%, respectively.
CONCLUSION: Results are comparable to partial or total laryngectomy, while being superior to primary chemo(radio)therapy. TLM results in low morbidity, rapid recovery, and good function and can be a valid option for organ-preserving surgery of pT3 glottic and supraglottic cancer.
METHODS: We conducted a retrospective case series study of 226 patients with pT3 glottic (n = 122; 54%) or supraglottic laryngeal carcinoma (n = 104; 46%). All patients were treated by TLM in combination with neck dissection (63%) and with postoperative radiotherapy (18%). Our main outcome measures were local control, organ preservation, functional outcome, overall survival, recurrence-free survival, and disease-specific survival.
RESULTS: Median follow-up period was 57.8 months. The 5-year organ-preservation and local control rates for all patients were 87% and 71.4%, respectively. The 5-year overall, recurrence-free, and disease-specific survival were 64.4%, 63.0%, and 83.3%, respectively.
CONCLUSION: Results are comparable to partial or total laryngectomy, while being superior to primary chemo(radio)therapy. TLM results in low morbidity, rapid recovery, and good function and can be a valid option for organ-preserving surgery of pT3 glottic and supraglottic cancer.
Предметные рубрики MeSH
AdultAgedCarcinoma, Squamous CellChemoradiotherapyDisease-Free SurvivalFeasibility StudiesFemaleGlottisHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaryngectomyLaser TherapyMaleMicrosurgeryMiddle AgedMinimally Invasive Surgical ProceduresNeck DissectionNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingOrgan Sparing TreatmentsPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival RateTreatment Outcome