[Central control of bone metabolism].

Leptin, a well-known adipokine regulating energy metabolism, inhibits bone formation via sympathetic nervous system. Recently, it was reported that adrenergic beta(2) receptor-deficient mice have high bone mass due to increased bone formation and decreased bone resorption. In addition, cocaine- and amphetamine-regulated transcript, an anorexigenic neuropeptide whose expression is regulated by leptin, has been shown to inhibit bone resorption. Thus, leptin regulates not only bone formation but bone resorption centrally.