Blood pressure responses and drinking following central angiotensin II in adult rats guanethidine-sympathectomised at birth.

Rats pups were sympathectomised with daily, for 3 weeks, injections of guanethidine (0.01 ml/g body weight), starting the second day after birth. They were separated from their respective dams at 6 weeks, and when they had reached their adult weight (350 g), the males were used to study the role of the sympathetic nervous system in the blood pressure and drinking responses to central injections of angiotensin II (AII, 250 ng). Littermates injected with 0.15 NaCl served as controls. Mean blood pressure was similar in both experimental and control groups (118 +/- 6 versus 128 +/- 4 mmHg) though the sympathectomised rats had a less stable baseline blood pressure than the controls. AII injected into the third cerebral ventricle produced similar increases in blood pressure and drinking responses in both groups. From these results we conclude that other systems appeared to have compensated for the lack of the sympathetic nervous system in normal blood pressure regulation and in stimulated (AII) blood pressure increases.