Acta oto-laryngologica · 2019
The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation.
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Wu Shufeng, Shi Huan, Cao Ningning, Ye Lei, Yu Chuangqi, Zheng Lingyan
Аннотация
BACKGROUND: Juvenile recurrent parotitis (JRP) is defined as recurrent parotid inflammation, generally associated with nonobstructive sialectasis of the parotid gland. In addition, the etiology remains unclear, probably immunologically mediated.
AIM: The purposes of the present study were to report the relationship between JRP and immune function from the measurement of the JRP patients' immunoglobulins and T-lymphocyte subset.
METHODS: Immunologic assay from 2014 to 2017 of 100 children diagnosed with JRP at Shanghai Ninth Hospital compared with the 100 normal children by age.
RESULTS: The CD4 level of JRP children aged >6 years was significant lower than the one of JRP preschool children (p < .05), while the IgG level was significant higher than the one of the JRP preschool children (p < .05). In comparison with the normal children, the value of CD8 T cells, immunoglobulin G (IgG), immunoglobulin E (IgE), immunoglobulin A (IgA) and C3 (p < .01) of JRP children was significant higher, while the value of CD4 T cells was lower (p < .01) in spite of age. What is more, the value of CD8 T cells of JRP preschool children was much significant higher than the one of the normal preschool children (p < .01).
CONCLUSION: The immune function of JRP patients may become disorder: the suppression cellular immune function and inadequate humoral immune expression.
AIM: The purposes of the present study were to report the relationship between JRP and immune function from the measurement of the JRP patients' immunoglobulins and T-lymphocyte subset.
METHODS: Immunologic assay from 2014 to 2017 of 100 children diagnosed with JRP at Shanghai Ninth Hospital compared with the 100 normal children by age.
RESULTS: The CD4 level of JRP children aged >6 years was significant lower than the one of JRP preschool children (p < .05), while the IgG level was significant higher than the one of the JRP preschool children (p < .05). In comparison with the normal children, the value of CD8 T cells, immunoglobulin G (IgG), immunoglobulin E (IgE), immunoglobulin A (IgA) and C3 (p < .01) of JRP children was significant higher, while the value of CD4 T cells was lower (p < .01) in spite of age. What is more, the value of CD8 T cells of JRP preschool children was much significant higher than the one of the normal preschool children (p < .01).
CONCLUSION: The immune function of JRP patients may become disorder: the suppression cellular immune function and inadequate humoral immune expression.
Предметные рубрики MeSH
AdolescentAge FactorsAnalysis of VarianceCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCase-Control StudiesChildChild, PreschoolChinaFemaleHospitals, PublicHumansImmunoglobulin AImmunoglobulin GMaleParotid GlandParotitisPrognosisRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex Factors