The Journal of clinical endocrinology and metabolism · 2023
An Iodine Balance Study in Chinese School-age Children.
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Guo Wenxing, Yang Ying, Jiang Wen, Cheng Yuangui, Wu Wen, Pan Ziyun, Zhang Dingyan, Li Shaohan, Ren Zhiyuan, Zhang Naifan, Zhang Kexin, Pearce Elizabeth N, Chen Wen, Zhang Wanqi
Аннотация
CONTEXT: Few iodine balance studies have been conducted in school-age children.
OBJECTIVE: This study aimed to conduct an iodine balance study in school-age children.
METHODS: We measured daily iodine intake, excretion, and retention for 3 consecutive days without any dietary interventions in school-age children. Linear mixed-effects models were used to fit the relationship between total iodine intake and iodine retention.
RESULTS: 29 children aged 7-12 years (mean age 10.2 ± 1.4 years) with normal thyroid function and thyroid volume were recruited. The 0 balance value (iodine intake = iodine excretion, iodine retention = 0 μg/day) shifted with iodine intake in an iodine sufficient population. The 0 balance value for school-age children with an iodine intake of 235 (133, 401) μg/day is 164 μg/day. Children aged 7-12 years with iodine intake >400 μg/day were almost all in a positive iodine state.
CONCLUSION: An iodine intake of 235 (133, 401) μg/day for children aged 7-10 years achieved a 0 balance value of 164 μg/day. Long-term iodine intake of >400 μg/day is not recommended.
OBJECTIVE: This study aimed to conduct an iodine balance study in school-age children.
METHODS: We measured daily iodine intake, excretion, and retention for 3 consecutive days without any dietary interventions in school-age children. Linear mixed-effects models were used to fit the relationship between total iodine intake and iodine retention.
RESULTS: 29 children aged 7-12 years (mean age 10.2 ± 1.4 years) with normal thyroid function and thyroid volume were recruited. The 0 balance value (iodine intake = iodine excretion, iodine retention = 0 μg/day) shifted with iodine intake in an iodine sufficient population. The 0 balance value for school-age children with an iodine intake of 235 (133, 401) μg/day is 164 μg/day. Children aged 7-12 years with iodine intake >400 μg/day were almost all in a positive iodine state.
CONCLUSION: An iodine intake of 235 (133, 401) μg/day for children aged 7-10 years achieved a 0 balance value of 164 μg/day. Long-term iodine intake of >400 μg/day is not recommended.