Nature communications · 2026
HuR coordinates systemic aging through platelet infiltration.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Liu Cihang, Wang Ying, Xia Tianjiao, Lin Jing, Liao Qianzan, Li Yanyan, Zhang Yiqiang, Miao Congxiu, Yi Xia, Sun Luyang, Ma Zhengliang, Cheng Xiaolei, Jiang Bin, Tian Feng, Ju Zhenyu, Liu Baohua, Kong Wei, Fu Yi, Yang Zhongzhou, Liu Junling, Tang Hao, Gu Xiaoping, Wang Wengong
Аннотация
Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in systemic aging. In aged mice, the levels of platelet-secreted pro-inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in the brain, liver, lung, kidney, and aortic root. The RNA-binding protein HuR/ELAVL1, a major regulator of RNA metabolism, promoted the production of PSPF in platelets. Platelet-specific deletion of HuR reduced the expression of PSPF in platelets, alleviated platelet infiltration in the brain, liver, lung, kidney, and aortic root, and delayed systemic aging. By using single-nucleus sequencing, platelet-specific HuR ablation was found to alleviate p53 and pro-inflammatory signaling pathways in liver, lung, and brain tissues in aged mice. Our findings highlight a role of platelets in coordinating aging traits across organs.