Archives of physiology and biochemistry · 2025
Halophyte decocted extract alleviates metabolic and histopathological disturbances induced in human-like rodent model, Psammomys obesus.
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Haffani Yosr Z, Chrigui Souhaieb, Khiari Ramla, Hammami Mohamed Bessem, Hadj Taieb Sameh, Feki Moncef, Ben Chaouacha-Chekir Rafika, Boudhrioua Nourhène
Аннотация
BACKGROUND: The effect of halophyte plant "Salicornia arabica" decocted extract (HDE) on histological damage and metabolic disorders induced by a High-Caloric Diet (HCD) in Psammomys obesus (P. obesus) was investigated.
METHODS: Forty P. obesus were divided into two groups: receiving a natural Low-Caloric Diet (LCD) or a high-caloric diet (HCD). On day 90, each group was further subdivided into two groups, with or without a daily oral administration of HDE at 300 mg/kg body weight for one month. Body weight, glycaemia, and serum lipid profile were assessed. Histopathological analyses on retinal, pancreatic, renal, and adipose tissues were conducted on day 120.
RESULTS: HDE administration markedly alleviates the HCD-induced metabolic disorder and histopathological alterations, restoring tissue integrity compared to the untreated HCD group. ATR-FTIR and micronutrient analyses showed HDE contains antioxidant minerals, soluble dietary fibers, and phenolic compounds likely responsible for its effects.
CONCLUSION: HDE may protect against HCD-induced metabolic disorders and tissues alteration in P. obesus.
METHODS: Forty P. obesus were divided into two groups: receiving a natural Low-Caloric Diet (LCD) or a high-caloric diet (HCD). On day 90, each group was further subdivided into two groups, with or without a daily oral administration of HDE at 300 mg/kg body weight for one month. Body weight, glycaemia, and serum lipid profile were assessed. Histopathological analyses on retinal, pancreatic, renal, and adipose tissues were conducted on day 120.
RESULTS: HDE administration markedly alleviates the HCD-induced metabolic disorder and histopathological alterations, restoring tissue integrity compared to the untreated HCD group. ATR-FTIR and micronutrient analyses showed HDE contains antioxidant minerals, soluble dietary fibers, and phenolic compounds likely responsible for its effects.
CONCLUSION: HDE may protect against HCD-induced metabolic disorders and tissues alteration in P. obesus.