Halophyte decocted extract alleviates metabolic and histopathological disturbances induced in human-like rodent model, Psammomys obesus.

BACKGROUND

The effect of halophyte plant "Salicornia arabica" decocted extract (HDE) on histological damage and metabolic disorders induced by a High-Caloric Diet (HCD) in Psammomys obesus (P. obesus) was investigated.

METHODS

Forty P. obesus were divided into two groups: receiving a natural Low-Caloric Diet (LCD) or a high-caloric diet (HCD). On day 90, each group was further subdivided into two groups, with or without a daily oral administration of HDE at 300 mg/kg body weight for one month. Body weight, glycaemia, and serum lipid profile were assessed. Histopathological analyses on retinal, pancreatic, renal, and adipose tissues were conducted on day 120.

RESULTS

HDE administration markedly alleviates the HCD-induced metabolic disorder and histopathological alterations, restoring tissue integrity compared to the untreated HCD group. ATR-FTIR and micronutrient analyses showed HDE contains antioxidant minerals, soluble dietary fibers, and phenolic compounds likely responsible for its effects.

CONCLUSION

HDE may protect against HCD-induced metabolic disorders and tissues alteration in P. obesus.