Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025
Sequential nutrition intervention guided by nutritional risk screening improves outcomes following CyberKnife radiotherapy for pancreatic cancer: A randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Wang Feifei, Zhang Liwei, Li Na, Zhao Dengcui, Su Xin, Liu Jing, Shen Xiaoqian, Zhang Sujing, Fang Haixian, Wang Cong
Аннотация
INTRODUCTION: Nutritional status may determine the outcomes of patients with pancreatic cancer. This study aimed to investigate the value of sequential nutrition intervention guided by nutritional risk screening for patients undergoing CyberKnife radiotherapy for pancreatic cancer.
METHODS: A total of 100 patients with pancreatic cancer were enrolled and randomly divided into a control group (n = 50) and a nutrition intervention group (n = 50). Nutritional status, immunity, QoL, and postoperative complications were compared between groups at baseline, 1 week, and 1 month post-intervention.
RESULTS: Pre-intervention, there were no significant differences in nutritional indicators, including total protein (TP), transferrin (TRF), albumin (ALB), or prealbumin (PA), between the two groups. Post-intervention, the nutrition intervention group exhibited higher TP, TRF, ALB, and PA levels compared to the control group at both one week and one month (P < 0.05). Similarly, no significant differences were observed in IgA, IgM, IgG, CD3+, CD4+, CD8+, or CD4+/CD8+ ratios pre-intervention. Post-intervention, the nutrition intervention group showed elevated IgA, IgM, IgG, CD3+, CD4+, and CD8+ levels compared to the control group (P < 0.05), while no significant intergroup difference was found in the CD4+/CD8+ ratio. Quality of life (QoL) scores were comparable pre-intervention but significantly improved in the nutrition intervention group post-intervention at both time points (P < 0.05). The nutrition intervention group also demonstrated a lower incidence of overall complications (P < 0.05).
CONCLUSION: Sequential nutrition intervention guided by nutritional risk screening effectively improves nutritional status, immune function, and QoL while reducing complications in pancreatic cancer patients undergoing CyberKnife radiotherapy, warranting clinical application.
METHODS: A total of 100 patients with pancreatic cancer were enrolled and randomly divided into a control group (n = 50) and a nutrition intervention group (n = 50). Nutritional status, immunity, QoL, and postoperative complications were compared between groups at baseline, 1 week, and 1 month post-intervention.
RESULTS: Pre-intervention, there were no significant differences in nutritional indicators, including total protein (TP), transferrin (TRF), albumin (ALB), or prealbumin (PA), between the two groups. Post-intervention, the nutrition intervention group exhibited higher TP, TRF, ALB, and PA levels compared to the control group at both one week and one month (P < 0.05). Similarly, no significant differences were observed in IgA, IgM, IgG, CD3+, CD4+, CD8+, or CD4+/CD8+ ratios pre-intervention. Post-intervention, the nutrition intervention group showed elevated IgA, IgM, IgG, CD3+, CD4+, and CD8+ levels compared to the control group (P < 0.05), while no significant intergroup difference was found in the CD4+/CD8+ ratio. Quality of life (QoL) scores were comparable pre-intervention but significantly improved in the nutrition intervention group post-intervention at both time points (P < 0.05). The nutrition intervention group also demonstrated a lower incidence of overall complications (P < 0.05).
CONCLUSION: Sequential nutrition intervention guided by nutritional risk screening effectively improves nutritional status, immune function, and QoL while reducing complications in pancreatic cancer patients undergoing CyberKnife radiotherapy, warranting clinical application.