Clinic-pathological study of gastro-duodenal ulcers from the standpoint of aging of the patients.

The gastric ulcer and duodenal ulcer resected surgically were investigated clinico-pathologically. The duodenal ulcers occurred frequently in the third to fourth decades in the patients with relatively normal gastric mucosal structure and high acid secretion. On the other hand, the gastric ulcer occurred frequently in the fifth to sixth decades in the patients with moderate to marked mucosal damage and subsequent intestinal metaplasia. Although the duodenal ulcers occurred frequently in the anterior wall, the gastric ulcers were usually found in the lesser curvature and posterior wall. Multiple lesions in the patients of gastric ulcer and linear lesion in the patients of duodenal ulcer increase by aging. The duodenal ulcers were found at the rate of 25% in the patients with gastric ulcer and the gastric ulcers were found at the rate of 40% in the patients with duodenal ulcer.