MedElevator
Войти в исследования Journal of diabetes and its complications · 2025
Data-driven subtypes of newly diagnosed youth-onset type 2 diabetes in the USA.
СтатьяПоддержка NIH: внешняя программаПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Guo Jiali, Li Zhongyu, Carrillo-Larco Rodrigo M, Hsia Daniel S, Harding Jessica L, Ali Mohammed K, Varghese Jithin Sam
Аннотация
AIMS: To identify subtypes of newly diagnosed youth-onset T2D using cluster analysis.
METHODS: A cross-sectional study included participants with T2D (duration ≤1 year) aged 10-19 years from the SEARCH for Diabetes in Youth Study (n = 304; 47.4 %) and aged 10-17 years from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (n = 337; 52.6 %) study before intervention allocation. We examined variables available in routine clinical practice. Main outcomes were data-driven subtypes identified using k-means clustering.
RESULTS: Among 641 participants with youth-onset T2D, 58.2 % were female. The analysis revealed three youth-onset subtypes: 48.5 % had obesity-related T2D (yOD), 18.7 % had insulin deficient T2D (yIDD), and 32.7 % had insulin resistant T2D (yIRD). The yOD subtype was characterized by high BMI and low HbA1c. The yIDD exhibited low fasting C-peptide levels, high HDL cholesterol, and high HbA1c. The yIRD subtype had high BMI, high fasting C-peptide, and high blood pressures compared to other subtypes. A higher prevalence of distal symmetric polyneuropathy was observed at diagnosis among yIDD and yIRD subtypes, relative to the yOD subtype.
CONCLUSIONS: Three subtypes of youth-onset T2D were identified with different clinical characteristics. Management of youth-onset T2D may require tailored strategies by subtype.
METHODS: A cross-sectional study included participants with T2D (duration ≤1 year) aged 10-19 years from the SEARCH for Diabetes in Youth Study (n = 304; 47.4 %) and aged 10-17 years from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (n = 337; 52.6 %) study before intervention allocation. We examined variables available in routine clinical practice. Main outcomes were data-driven subtypes identified using k-means clustering.
RESULTS: Among 641 participants with youth-onset T2D, 58.2 % were female. The analysis revealed three youth-onset subtypes: 48.5 % had obesity-related T2D (yOD), 18.7 % had insulin deficient T2D (yIDD), and 32.7 % had insulin resistant T2D (yIRD). The yOD subtype was characterized by high BMI and low HbA1c. The yIDD exhibited low fasting C-peptide levels, high HDL cholesterol, and high HbA1c. The yIRD subtype had high BMI, high fasting C-peptide, and high blood pressures compared to other subtypes. A higher prevalence of distal symmetric polyneuropathy was observed at diagnosis among yIDD and yIRD subtypes, relative to the yOD subtype.
CONCLUSIONS: Three subtypes of youth-onset T2D were identified with different clinical characteristics. Management of youth-onset T2D may require tailored strategies by subtype.