Hypofractionated radiotherapy for pancreatic cancer: What role in 2025?

The role of radiation therapy in the treatment of pancreatic cancer has been debated for many years. Recent advances in radiation techniques with the development of stereotactic body radiotherapy and magnetic resonance imaging-guided radiotherapy have opened new therapeutic possibilities, enabling the delivery of ablative doses while minimizing the dose received by surrounding organs at risk. In this context, the potential benefit of radiation therapy should be questioned again.