Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Mora Zetina Arlette Araceli, Ortega Sanchez Erika Fabiola, Zuñiga Ascencio Brenda Saraí, Castorena Maldonado Armando Roberto, Ahumada Topete Víctor Hugo, Torres Espíndola Luz María, Aquino Gálvez Arnoldo, Fernández Plata Rosario, Higuera Iglesias Anjarath Lorena, Martínez Briseño David, Bernal Silva Aranza, García Martín Misael Osmar, Márquez García José Eduardo, Moncada Morales Angelica, Chávez Alderete Jaime, Hernandez Zenteno Rafael, Becerril Vargas Eduardo, Cataneo Piña Daniela Josefina, Aguilar Faisal José Leopoldo, García Machorro Jazmín, López Sánchez Pedro, Hernandez Campos María Elena, Castillejos López Manuel
Аннотация
OBJECTIVE: To evaluate the evolution of angiogenic and thromboinflammatory biomarkers in post-COVID-19 syndrome patients.
METHODS: This ambispective cohort study was conducted at the National Institute of Respiratory Diseases in Mexico City. Thirty-two adults hospitalized for severe or critical COVID-19 in 2020 were followed for three and a half years. Paired plasma samples were collected during hospitalization and at long-term follow-up. Endothelial dysfunction markers included soluble P-selectin, vascular endothelial growth factor receptor 2, vascular endothelial growth factor D, and angiopoietin-1. Hemostasis was assessed by prothrombin time. Acute-phase proteins alpha-2-macroglobulin and haptoglobin were measured via immunoassay. Persistent symptoms were documented at follow-up.
RESULTS: At three and a half years, persistent symptoms were common: fatigue in sixty-five point 6%, dyspnea in sixty-two point 5%, and concentration difficulties in sixty-five point 6%. Vascular endothelial growth factor D and angiopoietin-1 remained elevated. Alpha-2-macroglobulin stayed high, and prothrombin time was prolonged in a subset of patients.
CONCLUSIONS: Severe COVID-19 survivors show sustained angiogenic dysregulation and thromboinflammatory imbalance. Elevated vascular endothelial growth factor D and angiopoietin-1 indicate ongoing angiogenic perturbations, while increased alpha-2-macroglobulin and prolonged prothrombin time reflect persistent coagulation disturbances. These biomarkers may help identify long-term vascular alterations in post-COVID-19 syndrome.