Journal of pediatric and adolescent gynecology · 2018
Irreversible Primary Amenorrhea Secondary to Uterine Damage and Premature Ovarian Failure in 2 Patients with Ewing Sarcoma.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Makri Angeliki, Boyce Alison M, Stratakis Constantine A, Lodish Maya
Аннотация
BACKGROUND: The long-term morbidity of childhood cancer survivors is an emerging field as more patients are now expected to live through adulthood.
CASE: We describe 2 adolescent patients with permanent premature ovarian failure and failure of endometrium to respond to estrogen after they received a combination of chemotherapy and pelvic radiation for metastatic Ewing sarcoma. Both girls were prepubertal at diagnosis of Ewing sarcoma. Puberty was induced with high-dose estrogen and progesterone; however, none of the patients had withdrawal bleeding.
SUMMARY AND CONCLUSION: It is critical to counsel these patients that menstruation might not be possible even with hormone replacement therapy.
CASE: We describe 2 adolescent patients with permanent premature ovarian failure and failure of endometrium to respond to estrogen after they received a combination of chemotherapy and pelvic radiation for metastatic Ewing sarcoma. Both girls were prepubertal at diagnosis of Ewing sarcoma. Puberty was induced with high-dose estrogen and progesterone; however, none of the patients had withdrawal bleeding.
SUMMARY AND CONCLUSION: It is critical to counsel these patients that menstruation might not be possible even with hormone replacement therapy.