Irreversible Primary Amenorrhea Secondary to Uterine Damage and Premature Ovarian Failure in 2 Patients with Ewing Sarcoma.

BACKGROUND

The long-term morbidity of childhood cancer survivors is an emerging field as more patients are now expected to live through adulthood.

CASE: We describe 2 adolescent patients with permanent premature ovarian failure and failure of endometrium to respond to estrogen after they received a combination of chemotherapy and pelvic radiation for metastatic Ewing sarcoma. Both girls were prepubertal at diagnosis of Ewing sarcoma. Puberty was induced with high-dose estrogen and progesterone; however, none of the patients had withdrawal bleeding.

SUMMARY AND

CONCLUSION

It is critical to counsel these patients that menstruation might not be possible even with hormone replacement therapy.