Study Designs for Exploring the Non-HLA Genetics in Celiac Disease.

Since the breakthrough of genome-wide association studies and genetic studies of common complex diseases like celiac disease have been able to finally identify reproducible gene regions affecting risk of developing disease. Before it was possible to perform genome-wide association analysis, the field struggled with genome-wide linkage analysis to identify gene regions. Genome-wide linkage had been very successful in identifying genes underlying monogenic diseases, but common complex polygenic diseases did not prove so tractable. This chapter will describe the genome-wide methods available for genetic analyses of families today and compare these with the previous analyses performed in the 1990s and early twenty-first century.