[The Effect of Platelet Irradiation on the Efficacy and Safety of Platelet Transfusion in Children with Hematological Disorders].

OBJECTIVE

To investigate the effect of platelet irradiation on the efficacy and safety of platelet transfusion in children with hematological disorders.

METHODS

The platelet transfusion of 56 pediatric patients in the Hematology Department of Wuhan Children's Hospital from January to December 2023 were retrospective analyzed. According to whether the platelets transfused by the patient have been irradiated, they are divided into irradiation group and non irradiation group. The effect of platelet irradiation on efficacy rate of transfusion and incidence of transfusion adverse reactions was analyzed.

RESULTS

Fifty-six patients with hematological disorders received 608 platelet transfusions, with 83 transfusions ineffective and an inefficiency rate of 13.65%. Twenty-nine times of adverse transfusion reactions occurred, with a transfusion reaction incidence rate of 4.77%. The 24-hour CCI value of the irradiation group was lower than that of the non irradiation group ( Z=4.120, P < 0.01), and the effective rate of transfusion in the irradiation group was lower than that in the non irradiation group (χ2=8.595, P <0.01). The incidence of adverse reactions during transfusion in the irradiation group was lower than that in the non irradiation group (χ2=4.153, P <0.05). In children with acute leukemia, there were statistical differences in 24 h CCI, the effective rate of transfusion, and adverse transfusion reactions between the irradiation and non-irradiation groups.

CONCLUSION

Platelet irradiation can reduce the effective rate of platelet transfusion in children with hematological disorders, but can reduce the incidence of adverse transfusion reactions. To ensure the safety of blood use for pediatric patients, it is recommended to transfuse irradiated platelets to individuals who are susceptible to transfusion associated graft-versus-host disease (TA-GVHD), especially children with acute leukemia.