Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
SEOM-GEINO clinical guideline of systemic therapy and management of brain central nervous system metastases (2021).
СтатьяКлинические рекомендацииНазвание и аннотация: Перевод пока не подготовлен
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Martínez-García María, Servitja Tormo Sonia, Vilariño Quintela Noelia, Arance Fernández Ana, Berrocal Jaime Alfonso, Cantos Sánchez de Ibargüen Blanca, Del Barco Berrón Sonia, García Campelo Rosario, Gironés Sarrió Regina, Manuel Sepúlveda-Sánchez Juan
Аннотация
Central nervous system (CNS) dissemination is a severe complication in cancer and a leading cause of cancer-related mortality. Brain metastases (BMs) are the most common types of malignant intracranial tumors and are reported in approximately 25% of patients with metastatic cancers. The recent increase in incidence of BMs is due to several factors including better diagnostic assessments and the development of improved systemic therapies that have lower activity on the CNS. However, newer systemic therapies are being developed that can cross the blood-brain barrier giving us additional tools to treat BMs. The guidelines presented here focus on the efficacy of new targeted systemic therapies and immunotherapies on CNS BMs from breast, melanoma, and lung cancers.