[Leukocyte glucocorticoid receptor and its mRNA levels in leukemia patients].

OBJECTIVE

To explore factors for differentiating non-Hodgkin's lymphoma cell leukemia (NHLCL) and acute lymphoblastic leukemia (ALL).

METHODS

Leukocyte glucocorticoid receptor (GR) and GR mRNA levels were measured in 22 NHLCL, 18 ALL, 10 chronic lymphocytic leukemia (CLL) patients and 6 healthy subjects by using radio-ligand binding assay and molecular hybridization using GR cDNA as the probe.

RESULTS AND

CONCLUSIONS

The leukocyte GR and GR mRNA levels were significantly different between NHLCL and ALL(P < 0.01), and could be used as parameters for differential diagnosis of these two types of leukemia.