British journal of haematology · 2007
Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies.
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Ying Jianming, Gao Zifen, Li Hongyu, Srivastava Gopesh, Murray Paul G, Goh Hwee Koon, Lim Chai Yen, Wang Yajun, Marafioti Teresa, Mason David Y, Ambinder Richard F, Chan Anthony T C, Tao Qian
Аннотация
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2'-deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.
Предметные рубрики MeSH
Biomarkers, TumorBurkitt LymphomaCadherinsCell Line, TumorCpG IslandsDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticGene SilencingHematologic NeoplasmsHodgkin DiseaseHumansLeukemiaLymphoma, Large B-Cell, DiffuseLymphoma, T-CellProtocadherinsReverse Transcriptase Polymerase Chain Reaction