Zhonghua zhong liu za zhi [Chinese journal of oncology] · 2006
[Expression of BCL-10 protein and the relationship with API2-MALT1 fusion gene in extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue].
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Li Lei, Li Gan-di, Jiang Wei, Yang Wen-xiu, Liu Wei-ping, Zhang Wen-yan, Li Ji-man, Tang Yuan
Аннотация
OBJECTIVE: To investigate the relationship of BCL-10 protein and API2-MALT1 fusion gene in MALT lymphoma.
METHODS: Specimens from 86 cases of MALT lymphoma were studied by immunohistochemical staining for BCL-10. RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene.
RESULTS: In all 10 cases of Hashimoto thyroiditis only cytoplasmic BCL-10 expression in lymphoid cells was observed. In 86 MALT lymphoma cases, 42 cases (48. 8%) exhibited BCL-10 expression in both nucleus and cytoplasm. API2-MALT1 fusion gene was detected in 35 cases (40. 7%) of MALT lymphoma. BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. 374,P = 0. 000).
CONCLUSION: BCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.
METHODS: Specimens from 86 cases of MALT lymphoma were studied by immunohistochemical staining for BCL-10. RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene.
RESULTS: In all 10 cases of Hashimoto thyroiditis only cytoplasmic BCL-10 expression in lymphoid cells was observed. In 86 MALT lymphoma cases, 42 cases (48. 8%) exhibited BCL-10 expression in both nucleus and cytoplasm. API2-MALT1 fusion gene was detected in 35 cases (40. 7%) of MALT lymphoma. BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. 374,P = 0. 000).
CONCLUSION: BCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.
Предметные рубрики MeSH
Adaptor Proteins, Signal TransducingB-Cell CLL-Lymphoma 10 ProteinCell NucleusCytoplasmFemaleFollow-Up StudiesGastric MucosaHashimoto DiseaseHumansImmunohistochemistryKaplan-Meier EstimateLymphoid TissueLymphoma, B-Cell, Marginal ZoneMaleMiddle AgedOncogene Proteins, FusionRespiratory MucosaReverse Transcriptase Polymerase Chain Reaction