Gastrointestinal endoscopy · 2014
ERCP-related adverse events in patients with primary sclerosing cholangitis.
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Navaneethan Udayakumar, Jegadeesan Ramprasad, Nayak Shishira, Lourdusamy Vennisvasanth, Sanaka Madhusudhan R, Vargo John J, Parsi Mansour A
Аннотация
BACKGROUND: ERCP is frequently used in patients with primary sclerosing cholangitis (PSC) for cancer surveillance and treatment of dominant strictures.
OBJECTIVE: To evaluate the prevalence and risk factors for ERCP-related adverse events in patients with PSC.
DESIGN: Retrospective analysis of ERCPs performed from 1998 to 2012.
SETTING: Referral center.
PATIENTS: A total of 294 consecutive patients with PSC who underwent a total of 657 ERCPs.
INTERVENTIONS: ERCP.
MAIN OUTCOME MEASUREMENTS: ERCP-related adverse events and predictive factors were determined by univariate and multivariate analyses.
RESULTS: ERCP use in patients with PSC showed a significant increase during the second half of the study period (2006-2012) compared with the first half (1998-2005) (437 vs 220 procedures; P = .04). Primary cannulation was successful in 634 procedures (96.6%) or in 271 of 294 patients (92.2%). Access to the bile duct was achieved with a needle-knife in 19 procedures (2.9%), whereas ERCP was unsuccessful in 4 of 657 procedures (0.6%), and successful percutaneous drainage was performed. Post-ERCP pancreatitis (PEP) was diagnosed in 8 (1.2%), cholangitis in 16 (2.4%), and bleeding in 4 (0.7%) procedures. Overall, risk of any adverse event was 28 of 657 (4.3%) procedures. On multivariate analysis, performing biliary sphincterotomy (odds ratio [OR] 5.04; 95% confidence interval [CI], 2.01-12.60; P = .001) and passage of a guidewire into the pancreatic duct (OR 4.54; 95% CI, 1.44-14.30; P = .010) were independently associated with an increased risk of any adverse event.
LIMITATIONS: Retrospective study.
CONCLUSION: Cholangitis appears to be the most common adverse event despite intraprocedural antibiotic use. There was a low risk of adverse events in patients with PSC undergoing ERCP.
OBJECTIVE: To evaluate the prevalence and risk factors for ERCP-related adverse events in patients with PSC.
DESIGN: Retrospective analysis of ERCPs performed from 1998 to 2012.
SETTING: Referral center.
PATIENTS: A total of 294 consecutive patients with PSC who underwent a total of 657 ERCPs.
INTERVENTIONS: ERCP.
MAIN OUTCOME MEASUREMENTS: ERCP-related adverse events and predictive factors were determined by univariate and multivariate analyses.
RESULTS: ERCP use in patients with PSC showed a significant increase during the second half of the study period (2006-2012) compared with the first half (1998-2005) (437 vs 220 procedures; P = .04). Primary cannulation was successful in 634 procedures (96.6%) or in 271 of 294 patients (92.2%). Access to the bile duct was achieved with a needle-knife in 19 procedures (2.9%), whereas ERCP was unsuccessful in 4 of 657 procedures (0.6%), and successful percutaneous drainage was performed. Post-ERCP pancreatitis (PEP) was diagnosed in 8 (1.2%), cholangitis in 16 (2.4%), and bleeding in 4 (0.7%) procedures. Overall, risk of any adverse event was 28 of 657 (4.3%) procedures. On multivariate analysis, performing biliary sphincterotomy (odds ratio [OR] 5.04; 95% confidence interval [CI], 2.01-12.60; P = .001) and passage of a guidewire into the pancreatic duct (OR 4.54; 95% CI, 1.44-14.30; P = .010) were independently associated with an increased risk of any adverse event.
LIMITATIONS: Retrospective study.
CONCLUSION: Cholangitis appears to be the most common adverse event despite intraprocedural antibiotic use. There was a low risk of adverse events in patients with PSC undergoing ERCP.