The Journal of infectious diseases · 2024
Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Bathini Praveen, Brai Emanuele, Balin Brian J, Bimler Lynn, Corry David B, Devanand Davangere P, Doty Richard L, Ehrlich Garth D, Eimer William A, Fulop Tamas, Hahn David L, Hammond Christine J, Infanti Joseph, Itzhaki Ruth, Lathe Richard, Little Christopher Scott, McLeod Rima, Moein Shima T, Nelson Amy R, Perry George, Shemesh Or A, Tanzi Rudolph E, Webley Wilmore C, Schultek Nikki M, Alberi Auber Lavinia
Аннотация
Sensory functions of organs of the head and neck allow humans to interact with the environment and establish social bonds. With aging, smell, taste, vision, and hearing decline. Evidence suggests that accelerated impairment in sensory abilities can reflect a shift from healthy to pathological aging, including the development of Alzheimer's disease (AD) and other neurological disorders. While the drivers of early sensory alteration in AD are not elucidated, insults such as trauma and infections can affect sensory function. Herein, we review the involvement of the major head and neck sensory systems in AD, with emphasis on microbes exploiting sensory pathways to enter the brain (the "gateway" hypothesis) and the potential feedback loop by which sensory function may be impacted by central nervous system infection. We emphasize detection of sensory changes as first-line surveillance in senior adults to identify and remove potential insults, like microbial infections, that could precipitate brain pathology.