Asian Pacific journal of cancer prevention : APJCP · 2025
The Determining of Pesticide Residue Levels in Children Diagnosed with Acute Leukemia in Cukurova Region, Turkiye.
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Yilmaz Sema, Daglioglu Nebile, Inandiklioglu Nihal, Atasoy Aydin Asli, Goren Ismail Ethem, Kupeli Serhan, Ozkan Ayse, Leblebisatan Goksel, Yagci Kupeli Begul, Sezgin Gulay, Boz Nihal, Barutcu Adnan, Bayram Ibrahim
Аннотация
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. in children. Children can be exposed to pesticides during pregnancy or by their parent carried out pesticides to home. The objective of this study was to study pesticide residues in both acute leukemia patients and healthy children.
METHODS: Twenty nine patients with acute leukemia [22 boys (76%) and 7 girls (24%)] and 33 healthy children [(19 boys (57%), 14 girls (43%)] were included in the study. We analyzed eight PCB (PCB 28, PCB 52, PCB 101, PCB 118, PCB 138, PCB 153, PCB 180 and PCB 202), HCB, three HCH isomers, 4,4'-DDT, 4,4'-DDD and 4,4'-DDE were investigated in bone marrow of newly diagnosed acute leukemia patients and peripheral blood samples of healthy children.
RESULTS: The most detectable OCPs were β-HCH, δ-HCH and PCB28, triflumizole and thiometon were commonly found as OPPs. The significant difference was found statistically between ALL cases and control group according to the residues of PCB28 (74,06±85,29), β-HCH (72,06±89,07) and δ-HCH (23,35±42,93) (p=0.001). Additionally, OPPs consisted triflumizole (7,23±9,17), thiometon (3,37±4,30) and halfenprox (1,90±3,22) showed distinctive difference statistically (p=0.001).
CONCLUSION: Pesticide residues were estimated significantly in bone marrow of leukemia patients should be considered an important for public health with the decreasing or preventing of pesticide exposure which have a role in leukemia ethiology.
METHODS: Twenty nine patients with acute leukemia [22 boys (76%) and 7 girls (24%)] and 33 healthy children [(19 boys (57%), 14 girls (43%)] were included in the study. We analyzed eight PCB (PCB 28, PCB 52, PCB 101, PCB 118, PCB 138, PCB 153, PCB 180 and PCB 202), HCB, three HCH isomers, 4,4'-DDT, 4,4'-DDD and 4,4'-DDE were investigated in bone marrow of newly diagnosed acute leukemia patients and peripheral blood samples of healthy children.
RESULTS: The most detectable OCPs were β-HCH, δ-HCH and PCB28, triflumizole and thiometon were commonly found as OPPs. The significant difference was found statistically between ALL cases and control group according to the residues of PCB28 (74,06±85,29), β-HCH (72,06±89,07) and δ-HCH (23,35±42,93) (p=0.001). Additionally, OPPs consisted triflumizole (7,23±9,17), thiometon (3,37±4,30) and halfenprox (1,90±3,22) showed distinctive difference statistically (p=0.001).
CONCLUSION: Pesticide residues were estimated significantly in bone marrow of leukemia patients should be considered an important for public health with the decreasing or preventing of pesticide exposure which have a role in leukemia ethiology.