Bone marrow transplantation · 2001
Remission of severe, intractable autoimmune haemolytic anaemia following matched unrelated donor transplantation.
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Pratt G, Kinsey S E
Аннотация
Immune-mediated haemolytic anaemia presenting post allogeneic bone marrow transplantation is often alloimmune in origin due to ABO or minor red cell incompatibilities. Autoimmune haemolytic anaemia is also recognised, is frequently difficult to treat and overall prognosis is often poor, usually from associated problems. Here, we present a case report of autoimmune haemolysis presenting in an 8-year-old boy 6 months post allogeneic bone marrow transplant requiring 4 years of immunosuppressive therapy before remission of haemolysis. This case report highlights the fact that it is possible for haemolysis to resolve post transplant even after years of immunosuppressive therapy.
Предметные рубрики MeSH
Adrenal Cortex HormonesAlemtuzumabAnemia, Hemolytic, AutoimmuneAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntibodies, NeoplasmBlood TransfusionBone Marrow TransplantationChildCombined Modality TherapyCranial IrradiationCyclophosphamideCyclosporineGraft vs Host DiseaseHumansImmunoglobulins, IntravenousImmunosuppressive AgentsLeukemia-Lymphoma, Adult T-CellLymphocyte DepletionMalePrednisoloneRemission InductionThalidomideTransplantation ConditioningTransplantation, HomologousWhole-Body Irradiation