Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008
Human papillomavirus infection in Barrett's oesophagus in the UK: an infrequent event.
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Rai N, Jenkins G J S, McAdam E, Hibbitts S J, Fiander A N, Powell N G
Аннотация
BACKGROUND: Human papillomavirus (HPV) infection has been reported in squamous cell carcinomas of the oesophagus and has been recently described in Barrett's oesophagus, a premalignant condition which may give rise to oesophageal adenocarcinoma.
OBJECTIVES: To investigate HPV infection in Barrett's oesophagus in a UK population.
STUDY DESIGN: DNA was extracted from 73 Barrett's oesophagus biopsies and examined for the presence of DNA for 14 high risk (HR) and 6 low risk (LR) HPV types.
RESULTS: HPV DNA was present in only 1 of 73 samples; genotyping indicated this was a high risk type 51 infection.
CONCLUSIONS: HPV infection appears unlikely to be a significant factor in the aetiology of Barrett's oesophagus in the UK.
OBJECTIVES: To investigate HPV infection in Barrett's oesophagus in a UK population.
STUDY DESIGN: DNA was extracted from 73 Barrett's oesophagus biopsies and examined for the presence of DNA for 14 high risk (HR) and 6 low risk (LR) HPV types.
RESULTS: HPV DNA was present in only 1 of 73 samples; genotyping indicated this was a high risk type 51 infection.
CONCLUSIONS: HPV infection appears unlikely to be a significant factor in the aetiology of Barrett's oesophagus in the UK.