Cell reports · 2025
CD8+MT+ effector T cells from enlarged tumor-draining lymph nodes enhanced anti-tumor immunity and improved prognosis in colorectal cancer.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Jiang Tiantongfei, Guan Xu, Wei Ran, Lv Chongwen, Zan Likun, Zhang Zhen, Jiao Shuai, Ma Jian, Cheng Pu, Zhao Jiaqi, Guo Jinyuan, Jiang Zheng, Liu Haiyi, Zou Shuangmei, Xu Juan, Wang Xishan, Li Yongsheng
Аннотация
Despite the critical role of tumor-draining lymph nodes (TDLNs) in immunity, their heterogeneity is poorly understood. We employ single-cell and bulk RNA sequencing (RNA-seq) to dissect the immune landscape of TDLNs in colorectal cancer (CRC) cohorts. We reveal that enlarged TDLNs (L-TDLNs) are enriched with CD8+ effector T (Teff) cells exhibiting a distinct metallothionein (MT)-positive signature. CD8+MT+ Teff cells exhibit heightened cytotoxicity and a stress-adapted phenotype, which are critical mediators of anti-tumor immunity. CD8+MT+ Teff cells originate from L-TDLNs, where they undergo specific differentiation, and subsequently migrate to tumor. Moreover, patients with a high level of CD8+MT+ Teff cells in tumor show a significant survival advantage, in particular those treated with adjuvant chemotherapy. These findings highlight the importance of L-TDLNs in shaping effective anti-tumor immune responses, proposing the CD8+MT+ Teff cells as a prognostic biomarker and potential therapeutic target in CRC.