Journal of the American Academy of Dermatology · 2016
Pediatric melanomas often mimic benign skin lesions: A retrospective study.
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Mitkov Mario, Chrest Marie, Diehl Nancy N, Heckman Michael G, Tollefson Megha, Jambusaria-Pahlajani Anokhi
Аннотация
BACKGROUND: Childhood melanoma can be misdiagnosed because of its rarity and atypical presentation.
OBJECTIVE: We sought to correlate the clinical appearance of pediatric melanomas with Breslow depth and clinical behavior, and to identify diagnostic errors made by dermatologists and nondermatologist physicians.
METHODS: This was a retrospective review of Mayo Clinic records of children and young adults 21 years of age or younger with a diagnosis of primary cutaneous melanoma between January 2000 and January 2015.
RESULTS: Pediatric melanomas that mimicked benign skin lesions were more often deeper (>1 mm; odds ratio 5.48; P = .002) and had a higher T stage (odds ratio [T2, T3, or T4] 6.28; P = .001) than melanomas with a clinically malignant appearance. Of pediatric melanomas, 66% originally diagnosed as benign melanocytic lesions exhibited changes in size, shape, and color.
LIMITATIONS: Sample size and retrospective design are limitations.
CONCLUSIONS: Benign-appearing pediatric skin lesions with a history of evolution, bleeding, or ulceration should raise suspicion for melanoma. Melanomas demonstrating these features are associated with a higher Breslow depth and T stage. Although biopsy of all lesions that exhibit change in children is not practical, safe, or desired, close monitoring is recommended.
OBJECTIVE: We sought to correlate the clinical appearance of pediatric melanomas with Breslow depth and clinical behavior, and to identify diagnostic errors made by dermatologists and nondermatologist physicians.
METHODS: This was a retrospective review of Mayo Clinic records of children and young adults 21 years of age or younger with a diagnosis of primary cutaneous melanoma between January 2000 and January 2015.
RESULTS: Pediatric melanomas that mimicked benign skin lesions were more often deeper (>1 mm; odds ratio 5.48; P = .002) and had a higher T stage (odds ratio [T2, T3, or T4] 6.28; P = .001) than melanomas with a clinically malignant appearance. Of pediatric melanomas, 66% originally diagnosed as benign melanocytic lesions exhibited changes in size, shape, and color.
LIMITATIONS: Sample size and retrospective design are limitations.
CONCLUSIONS: Benign-appearing pediatric skin lesions with a history of evolution, bleeding, or ulceration should raise suspicion for melanoma. Melanomas demonstrating these features are associated with a higher Breslow depth and T stage. Although biopsy of all lesions that exhibit change in children is not practical, safe, or desired, close monitoring is recommended.
Предметные рубрики MeSH
AdolescentAge DistributionBiopsy, NeedleChildChild, PreschoolCohort StudiesDiagnosis, DifferentialFemaleHumansImmunohistochemistryIncidenceMaleMelanomaMultivariate AnalysisOdds RatioPediatricsRetrospective StudiesRisk AssessmentSex DistributionSkin DiseasesSkin NeoplasmsYoung AdultCutaneous Malignant Melanoma