Anticancer research · 2011
Expression of mucin-1, galectin-1 and galectin-3 in human leiomyosarcoma in comparison to leiomyoma and myometrium.
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Weissenbacher Tobias, Kuhn Christina, Mayr Doris, Pavlik Roman, Friese Klaus, Scholz Christoph, Jeschke Udo, Ditsch Nina, Dian Darius
Аннотация
BACKGROUND: The potential mechanism of malignant transformation from leiomyoma to leiomyosarcoma is still debated. The aim was the evaluation of expression patterns of mucin-1 (MUC1) (MUC1 VU-4-H5), galectin-1 (Gal-1) and galectin-3 (Gal-3) in human myometrium and leiomyoma and in comparison to leiomyosarcoma.
MATERIALS AND METHODS: Myometrium, leiomyoma and leiomyosarcoma tissues were obtained from 79 patients. Samples were analyzed regarding the expression of MUC1, Gal-1 and Gal-3 by immunohistochemical staining of paraffin-embedded material.
RESULTS: The expression of MUC1 (VU4-H5) was up-regulated in leiomyoma (p = 0.065) and leiomyosarcoma (p = 0.039) as compared to the myometrium. In contrast, there were no significant differences in expression of Gal-3 in the tissues from the myometrium, myoma and leiomyosarcoma. Concerning Gal-1 expression, the differences were not significant comparing myometrium and leiomyosarcoma (p = 0.277). Myoma had elevated levels of Gal-1 compared to myometrium (p = 0.007) and leiomyosarcoma (p < 0.0001).
CONCLUSION: MUC1 and Gal-1 might be useful for evaluating the potential of leiomyoma to transform into leiomyosarcoma and, therefore, help in risk-adapted consultation and adjusted treatment.
MATERIALS AND METHODS: Myometrium, leiomyoma and leiomyosarcoma tissues were obtained from 79 patients. Samples were analyzed regarding the expression of MUC1, Gal-1 and Gal-3 by immunohistochemical staining of paraffin-embedded material.
RESULTS: The expression of MUC1 (VU4-H5) was up-regulated in leiomyoma (p = 0.065) and leiomyosarcoma (p = 0.039) as compared to the myometrium. In contrast, there were no significant differences in expression of Gal-3 in the tissues from the myometrium, myoma and leiomyosarcoma. Concerning Gal-1 expression, the differences were not significant comparing myometrium and leiomyosarcoma (p = 0.277). Myoma had elevated levels of Gal-1 compared to myometrium (p = 0.007) and leiomyosarcoma (p < 0.0001).
CONCLUSION: MUC1 and Gal-1 might be useful for evaluating the potential of leiomyoma to transform into leiomyosarcoma and, therefore, help in risk-adapted consultation and adjusted treatment.