Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort.
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Tozzi Leonardo, Garczarek Lisa, Janowitz Deborah, Stein Dan J, Wittfeld Katharina, Dobrowolny Henrik, Lagopoulos Jim, Hatton Sean N, Hickie Ian B, Carballedo Angela, Brooks Samantha J, Vuletic Daniella, Uhlmann Anne, Veer Ilya M, Walter Henrik, Bülow Robin, Völzke Henry, Klinger-König Johanna, Schnell Knut, Schoepf Dieter, Grotegerd Dominik, Opel Nils, Dannlowski Udo, Kugel Harald, Schramm Elisabeth, Konrad Carsten, Kircher Tilo, Jüksel Dilara, Nenadić Igor, Krug Axel, Hahn Tim, Steinsträter Olaf, Redlich Ronny, Zaremba Dario, Zurowski Bartosz, Fu Cynthia H Y, Dima Danai, Cole James, Grabe Hans J, Connolly Colm G, Yang Tony T, Ho Tiffany C, LeWinn Kaja Z, Li Meng, Groenewold Nynke A, Salminen Lauren E, Walter Martin, Simmons Alan N, van Erp Theo G M, Jahanshad Neda, Baune Bernhard T, van der Wee Nic J A, van Tol Marie-Jose, Penninx Brenda W J H, Hibar Derrek P, Thompson Paul M, Veltman Dick J, Schmaal Lianne, Frodl Thomas, ‘for the ENIGMA-MDD Consortium’
Аннотация
METHODS: Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.
RESULTS: CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.
CONCLUSIONS: Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.