Medicina clinica · 2000
[Mutational analysis of p53 in T-cell lymphoblastic leukemia].
Сравнительное исследованиеАннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Nomdedéu J F, Badell I, Estivill C, del Río E, Sierra J, Baiget M
Аннотация
BACKGROUND: p53 mutations were analysed in a consecutive series of patients with T-ALL from one hospital over a period of 9 years.
PATIENTS AND METHOD: Thirty two samples from 27 patients with T-ALL were included in the study. Exons 5-9 were analysed using SSCP.
RESULTS: A mutation at codon 273 was identified in a child in third relapse. The mutated clone became dominant in a sample obtained one month following a course of salvage chemotherapy.
CONCLUSION: p53 mutations are not frequent in T-ALL even in patients at relapse.
PATIENTS AND METHOD: Thirty two samples from 27 patients with T-ALL were included in the study. Exons 5-9 were analysed using SSCP.
RESULTS: A mutation at codon 273 was identified in a child in third relapse. The mutated clone became dominant in a sample obtained one month following a course of salvage chemotherapy.
CONCLUSION: p53 mutations are not frequent in T-ALL even in patients at relapse.