Journal of tropical pediatrics · 2019
Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Sun Huiming, Sun Jiyang, Ji Wei, Hao Chuangli, Yan Yongdong, Chen Zhengrong, Wang Yuqing
Аннотация
OBJECTIVE: The objective of this study was to assess epidemiological and clinical features of human bocavirus (HBoV) coinfection with other viruses.
METHOD: Children coinfected with HBoV between January 2012 and December 2014 were enrolled and retrospectively reviewed.
RESULT: A total of 984 patients were stratified into five groups: HBoV infection alone (n = 249), respiratory syncytial virus (RSV) infection alone (n = 649), HBoV coinfection with RSV (n = 28), with human rhinovirus (HRV) (n = 39) and with other virus (n = 19). Length of hospitalization was longer in HBoV coinfection with RSV group than HBoV (9.0 days vs. 7.0 days, p = 0.001), RSV (9.0 days vs. 8.0 days, p = 0.016) infection alone group. Pneumonia was more common in the HBoV coinfection with RSV group compared with the HBoV, RSV infection alone group, respectively (75.0% vs. 44.2%, 31.3%, p < 0.001). HBoV DNA copy numbers (383 000 copies/ml) were positively correlated with the length of hospitalization (r = 0.334, p < 0.001).
CONCLUSION: HBoV coinfection with RSV increases HBoV infection severity.
METHOD: Children coinfected with HBoV between January 2012 and December 2014 were enrolled and retrospectively reviewed.
RESULT: A total of 984 patients were stratified into five groups: HBoV infection alone (n = 249), respiratory syncytial virus (RSV) infection alone (n = 649), HBoV coinfection with RSV (n = 28), with human rhinovirus (HRV) (n = 39) and with other virus (n = 19). Length of hospitalization was longer in HBoV coinfection with RSV group than HBoV (9.0 days vs. 7.0 days, p = 0.001), RSV (9.0 days vs. 8.0 days, p = 0.016) infection alone group. Pneumonia was more common in the HBoV coinfection with RSV group compared with the HBoV, RSV infection alone group, respectively (75.0% vs. 44.2%, 31.3%, p < 0.001). HBoV DNA copy numbers (383 000 copies/ml) were positively correlated with the length of hospitalization (r = 0.334, p < 0.001).
CONCLUSION: HBoV coinfection with RSV increases HBoV infection severity.