Effects of Ripasudil Hydrochloride Hydrate Instillation on Pupil Dynamics.

PURPOSE: We investigated the effects of instillation of ripasudil hydrochloride hydrate (GLANATEC®) on pupil dynamics.

MATERIALS AND

METHODS

Fourteen healthy participants (mean age: 30 years), who had no ophthalmic diseases other than refractive error, were enrolled in this study. A single dose of GLANATEC® was instilled into the left eye only. The pupillary response was measured before and 30 and 120 min after instillation; we also measured intraocular pressure (IOP) at the same time points.

RESULTS

The IOP in the left eye was significantly lower at both 30 (p < 0.05) and 120 (p < 0.01) min after instillation than at baseline, whereas that in the right eye was not significantly different from baseline at either of the measured post-instillation time points. In contrast, the pupillary response did not significantly differ between the three time points.

CONCLUSIONS

A single instillation of low concentration GLANATEC® may have no effect on pupil diameter and pupillary response.