Asian Pacific journal of cancer prevention : APJCP · 2012
Multidrug resistance-associated protein 1 predicts relapse in Iranian childhood acute lymphoblastic leukemia.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Mahjoubi Frouzandeh, Akbari Soodeh
Аннотация
Multidrug resistance (MDR) is a main cause of failure in the chemotherapeutic treatment of malignant disorders. One of the well-known genes responsible for drug resistance encodes the multidrug resistance- associated protein (MRP1). The association of MRP1 with clinical drug resistance has not systematically been investigated in Iranian pediatric leukemia patients. We therefore applied real-time RT-PCR technology to study the association between the MRP1 gene and MDR phenotype in Iranian pediatric leukemia patients. We found that overexpression of MRP1 occurred in most Iranian pediatric leukemia patients at relapse. However, no relation between MRP1 mRNA levels and other clinical characteristics, including cytogenetic subgroups and FAB subtypes, was found.
Предметные рубрики MeSH
ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1AdolescentCase-Control StudiesChildChild, PreschoolDrug Resistance, MultipleDrug Resistance, NeoplasmFemaleFollow-Up StudiesHumansMaleNeoplasm Recurrence, LocalNeoplasm StagingPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisRNA, MessengerRemission InductionReverse Transcriptase Polymerase Chain Reaction