Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 1999
[Rat submandibular gland tumor induced by 3-methylcholanthrene].
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Cao X, Liu X, He W, Liu X, Hao Z, Zhao Q
Аннотация
OBJECTIVE: To study the genesis and the development of salivary gland tumor (SGT).
METHODS: SGT animal models were established by injection of 3-methylcholanthrene (3-MCA) oil solution into 40 submandibular glands of Sprague-Dawley (SD) rats, then histopathology and ultrastructure of induced tumors were observed under microscope, and immunohistochemical detection of keratin and actin was carried out.
RESULTS: 32 models of submandibular gland tumors were induced successfully, with 4 rats of squamous cell carcinoma and 28 leiomyosarcoma, and the carcinogenesis of 3-MCA and tissue genesis of induced tumors were discussed.
CONCLUSION: Submandibular gland tumor can be induced by 3-MCA, and sarcoma was of high incidence.
METHODS: SGT animal models were established by injection of 3-methylcholanthrene (3-MCA) oil solution into 40 submandibular glands of Sprague-Dawley (SD) rats, then histopathology and ultrastructure of induced tumors were observed under microscope, and immunohistochemical detection of keratin and actin was carried out.
RESULTS: 32 models of submandibular gland tumors were induced successfully, with 4 rats of squamous cell carcinoma and 28 leiomyosarcoma, and the carcinogenesis of 3-MCA and tissue genesis of induced tumors were discussed.
CONCLUSION: Submandibular gland tumor can be induced by 3-MCA, and sarcoma was of high incidence.