Медицинская библиотека · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 1999

[Rat submandibular gland tumor induced by 3-methylcholanthrene].

Cao X, Liu X, He W, Liu X, Hao Z, Zhao Q

Аннотация на английскомСтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

To study the genesis and the development of salivary gland tumor (SGT).

METHODS

SGT animal models were established by injection of 3-methylcholanthrene (3-MCA) oil solution into 40 submandibular glands of Sprague-Dawley (SD) rats, then histopathology and ultrastructure of induced tumors were observed under microscope, and immunohistochemical detection of keratin and actin was carried out.

RESULTS

32 models of submandibular gland tumors were induced successfully, with 4 rats of squamous cell carcinoma and 28 leiomyosarcoma, and the carcinogenesis of 3-MCA and tissue genesis of induced tumors were discussed.

CONCLUSION

Submandibular gland tumor can be induced by 3-MCA, and sarcoma was of high incidence.

Для цитирования: Cao X, Liu X, He W, Liu X, Hao Z, Zhao Q. [Rat submandibular gland tumor induced by 3-methylcholanthrene].. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. 1999.

Предметные рубрики MeSH

Animals Carcinoma, Squamous Cell Leiomyosarcoma Methylcholanthrene Rats Rats, Sprague-Dawley Submandibular Gland Neoplasms

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