Role of serotonin in systemic impairment of motor function of the digestive tract.

We studied the role of serotonin in systemic impairment of motor function of the digestive tract. Administration of a nitric oxide donor methylene blue into the pre-fundal portion of the stomach and application of a loose ligature to the terminal part of the sigmoid colon were performed after pretreatment with serotonin. Serotonin had a stabilizing effect on esophageal antiperistalsis under conditions of dynamic obstruction of the sigmoid colon.